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Center for Clinical Epidemiology



Center for Clinical Epidemiology
Research Unit for Clinical Epidemiology
Odense University Hospital
Kløvervænget 30, entrance 216, ground floor, east
Tel: +45 2115 3599

Email: Susanne.moellerstroem@rsyd.dk


CCE Research Strategy


Biomarkers in bacteraemia patients: a collaboration project with Tan Tock Seng Hospital, Singapore

Recently, a Data Processor Agreement and a Research Collaboration Agreement has been signed between Center for Clinical Epidemiology, OUH, and Department of Clinical Epidemiology, Tan Tock Seng Hospital (TTSH), Singapore.

The project comprises 35,000 first-time bacteraemic episodes, half from OUH and half from TTSH. An estimated number of 350,000 C-reactive protein, serum albumin, and haemoglobin specimens will be analysed in relation to these bacteraemic episodes. Analyses will focus on changes in these biomarker levels. These changes will be related to the patients’ comorbidity and bacteraemic episodes to elucidate whether they are mainly markers of acute or chronic conditions or exacerbations. The biomarkers and their changes will further be incorporated into prognostic models. The high numbers of specimens enable the development of models that take into account different numbers of and time intervals between measurements. This is in order to minimize the impact of confounding by indication, which may be a major bias in real-life data.

Web sites:

Department of Epidemiology, TTSH: https://www.ttsh.com.sg/Clinical_Epidemiology/

TTSH: https://www.ttsh.com.sg/aboutTTSH/

More information:

Kim Oren Gradel, Center for Clinical Epidemiology, e-mail kim.gradel@rsyd.dk






Professor Pedro Manuel Sarmento Rodrigues Póvoa, Unidade de Cuidados Intensivos Polivalente, Hospital de São Francisco Xavier, CHLO, Lissabon, Portugal is apppointed Adjunct Professor in critical care, emergency medicine, use of biomarkers, and longitudinal data analyses as of 1 December 2017 through 30 November 2022


As of 1 July 2017 the center's affiliation with Brigham and Women’s Hospital and Harvard Medical School has been prolonged and Bente Mertz Nørgård appointed 1) Senior Epidemiologist at BWH and 2) Lecturer, part-time at Harvard Medical School




Center for Clinical Epidemiology has been an independent department at Odense University Hospital (OUH) since 2007 and is organizationally linked with the staff department Quality, Research, Innovation, and Education, OUH.

Clinical epidemiology and clinical epidemiological research are key functions with regard to evidence based patient treatment in a modern health care system and thus a key function in a modern university hospital.

Clinical epidemiology is a scientific discipline focusing on the patient, and clinical epidemiology includes analyses of the patients’ prognoses, for example which factors are of importance for the recovery or death of the patient. Diagnosis and treatment are key predictors for the patients’ prognosis, and therefore these two elements constitute the main cornerstone of clinical epidemiology, and the quality of diagnosis and treatment are key elements in the practice of evidence based patient treatment.


In Center for Clinical Epidemiology we perform clinical epidemiology at an international level. The aim is to support the improvement of patients’ diagnostics and treatment, and to improve the provided clinical quality of care, and we thus aim to improve the prognosis of the patients through

·        Consultancy to clinical departments and health care authorities within clinical epidemiology and analysis

·        Research at the highest international level within patient diagnostics, treatment, and prognosis

·        Development of methodologies for quality assessment within the health care system

·        Research training

The center activities can be divided into:


1.    Consultancy within clinical epidemiology and analysis
The center offers consultancy to a number of business partners / cooperators (local, regional, national) within clinical epidemiology, data analysis and various research assisting tasks. All projects are related to clinical epidemiology, diagnostics and treatment. Several research units at the regional hospitals have separate agreements with Center for Clinical Epidemiology, for example about the research unit having a half-time equivalent biostatistics at its disposal (for payment).

2.    Research
All research activities at the center is affiliated with the Department of Clinical Research, University of Southern Denmark. We perform clinical research at an international level in cooperation with local, regional, national and international researchers and research institutions. The research unit publishes 25-30 peer reviewed papers internationally each year and receives research grants (national and international).
Adjunct professor Sonia Friedman, Brigham and Women’s Hospital, Boston and Harvard Medical School, USA, is affiliated with the Center for Clinical Epidemiology, and Professor Bente Mertz Nørgård, Odense University Hospital has been affiliated with Harvard Medical School as visiting professor since 2015. A number of staff members at the center have also formal employment at the  
Department  of Clinical Research, University of Southern Denmark, as associate professors.
Center for Clinical Epidemiology trains PhD-students and staff members at the center are supervisors for a number of PhD-students, medical bachelor students, and research fellow students.






Siden er sidst opdateret: 14-12-2018 af Odense Universitetshospital.